+: database providing this function;

-: database do not providing this function;

NA: data or attribute could not obtained from corresponding paper and database website;

* TCM basic theory:

Drug combination theory (Yao et al., 2013)

Dissection nature of "qi" and "blood" in TCM (Liu et al., 2013)

Types of coronary artery disease in TCM (Zhou and Wang,2014)

herbal medicine synergy (Wang et al., 2013)

Mechanisms of action for TCM formula (Li et al., 2012)

** New drug development:

Development of new herbal combination (Li et al., 2014)

Discovery new active components from herbs (Zheng et al., 2013)

Screening active components from herbs (Tao et al., 2013)

References:

Li,P. et al. (2014) Systems pharmacology strategies for drug discovery and combination with applications to cardiovascular diseases. J. Ethnopharmacol., 151, 93–107.

Li,X. et al. (2012) A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment. PLoS ONE, 7, e43918.

Liu,J. et al. (2013) A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets. Evid.Based Complement. Alternat. Med., 2013, 1–17.

Tao,W. et al. (2013) Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease. J. Ethnopharmacol., 145, 1–10.

Wang,X. et al. (2013) Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication. Integr. Biol., 5, 351.

Yao,Y. et al. (2013) Deciphering the combination principles of Traditional Chinese Medicine from a systems pharmacology perspective based on Ma-huang Decoction. J.Ethnopharmacol., 150, 619–638.

Zheng,C. et al. (2013) Systems-level Multi-target Drug Discovery from Natural Products with Applications to Cardiovascular Diseases. Mol. Divers., In revision.

Zhou,W. and Wang,Y. (2014) A network-based analysis of the types of coronary artery disease from traditional Chinese medicine perspective: Potential for therapeutics and drug discovery. J. Ethnopharmacol., 151, 66–77.