| Molecule ID | Mol1310 |
|---|---|
| Molecule name | Corylifolinin |
| Download structure (click to download) |  |
| Pharmacological and molecular properties | |
| InChIKey | DUWPGRAKHMEPCM-IZZDOVSWSA-N |
| Formular | C20H20O4 |
| Activity | Human Neuroblastoma cells, IMR-32, IC50=5.61μM; NB-39, IC50=6.22μM; Normal cells, Cerebellar granule cells, IC50=>100μM; OVCAR-8, IC50=7.92±0.96μM(72 h); PC3, IC50=15.06±0.80μM(72 h); A549, IC50=32.20±0.90μM(72 h); MCF-7, IC50=28.29±0.57μM(72 h); L-02, IC50=31.61±0.68μM(72 h); HUVEC, IC50=31.30±2.00μM(72 h); IMR-32, IC50=5.61μM(48h); NB-39, IC50=6.22μM(48h); cisplatin (control, IMR-32, IC50=64.0μM(48h); NB-39, IC50=8.95μM(48h);); |
| CAS | ♦ 20784-50-3 |
| Molecule synonyms | |
| Related targets | |
| Related Herbs | |
| Reference | [1] Zhou, J., Xie, G. and Xinjian, Y. (2012) Anticancer active components in TCM. TCM series of active components. Science Press, Bei Jing. [2] Jing H, Zhou X, Dong X, et al. Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells[J]. Cancer letters, 2010, 294(2): 167-177. [3] Nishimura R, Tabata K, Arakawa M, et al. Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma[J]. Biological and Pharmaceutical Bulletin, 2007, 30(10): 1878-1883. [4] Victor Kuete and Louis P. Sandjo, Isobavachalcone: An Overview, Chin J Integr Med 2012 Jul;18(7):543-547 |