| Molecule ID | Mol0977 |
|---|---|
| Molecule name | Lupeol |
| Download structure (click to download) |  |
| Pharmacological and molecular properties | |
| InChIKey | MQYXUWHLBZFQQO-QGTGJCAVSA-N |
| Formular | C30H50O |
| Activity | rat W256; HT1080, ED50=16.7μg/mL (control, Adriamycin, ED50=0.1μg/mL); MCF-7 breast cancer , GI50=75.6±11.7μmol/L (control, doxorubicin, GI50=42.8±8.2μmol/L); NCI-H460, GI50=86.1±12.4μmol/L (control, doxorubicin, GI50=94.0±8.7μmol/L); SF268, GI50=80.9±2.6μmol/L (control, doxorubicin, GI50=93.0±7.0μmol/L); NSCLCN6, IC50>30μg/mL; A549, inhibitory rate=79.1% (50μg/ml); HL-60, IC50=51.66±1.31μg(48h); HCT-116, IC50=28.97±1.370μg(48h); hypodiploid nuclei of HL-60 cells were increased to 28.5, 42.0 and 70.9% after a 3-day treatment with 75, 100 and 150 µM lupeol, respectively |
| CAS | ♦ 545-47-1 |
| Molecule synonyms | |
| Related targets | |
| Related Herbs | |
| Reference | [1] Aratanechemuge Y, Hibasami H, Sanpin K, et al. Induction of apoptosis by lupeol isolated from mokumen (Gossampinus malabarica L. Merr) in human promyelotic leukemia HL-60 cells[J]. Oncology reports, 2004, 11(2): 289-292. [2] Nhiem N X, Thu V K, Van Kiem P, et al. Cytotoxic oleane-type triterpene saponins from Glochidion eriocarpum[J]. Archives of pharmacal research, 2012, 35(1): 19-26. [3] 王斌, 姜登钊, 李国强, 等. 柽柳抗肿瘤萜类成分研究[J]. 中草药, 2009 (5): 697-701. [4] Reddy N M. Solanum xanthocarpum Chemical Constituents and Medicinal Properties: A Review[J].Scholars Academic Journal of Pharmacy,2014; 3(2): 146-149 [5] Zhou, J., Xie, G. and Xinjian, Y. (2012) Anticancer active components in TCM. TCM series of active components. Science Press, Bei Jing. [6] |